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Dyspnea or Dyspnoea (Pronounced disp-nee-ah, from the Latin dyspnoea, Greek dyspnoia. Define dyspnea Translate dyspnea. Definition of exertional dyspnea from the online medical dictionary hosted by mondofacto. Although dyspnea has been defined in several ways, 1, 2, 3, 4 we define it as "an uncomfortable sensation of breathing." This review will focus on the mechanisms of dyspnea, because a. dyspnea: difficult, labored breathing; shortness of breath. dysregulation: interruption of or interference with normal processes. dysthymia: chronic, mild depression; prolonged.